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Synovial sarcoma is a rare and aggressive soft tissue cancer that most often develops near the joints of the arms or legs. In very rare cases, however, it can appear in unusual locations — including the skull and brain region. A newly published case report describes a patient diagnosed with primary cranial synovial sarcoma who […]
We are incredibly honored to share that the Synovial Sarcoma Foundation received First Place in the Advocacy in Action Award at the 16th Annual SPAGN Conference in Stockholm, Sweden. Hosted by the Sarcoma Patient Advocacy Global Network (SPAGN), this award recognizes advocacy initiatives making a meaningful impact for sarcoma patients, families, clinicians, and researchers around […]
[Philadelphia, PA] The Synovial Sarcoma Foundation (SSF) is honored to welcome Lucia Manzinello Belluco and Roberto Belluco to its Board of Directors as the organization’s first European board members. Their appointment marks an important step in expanding the foundation’s international reach and strengthening collaboration across the global synovial sarcoma community. Lucia brings more than 20 […]
Developing treatments for rare cancers like synovial sarcoma remains one of the biggest challenges in modern medicine—but recent progress shows what’s possible. One major milestone came with the FDA approval of Tecelra, the first engineered T-cell therapy approved for a solid tumor in the U.S., including synovial sarcoma. Why Rare Cancers Face Unique Challenges Synovial […]
Synovial sarcoma is a rare and aggressive soft tissue cancer, but new research is helping us better understand how it behaves—and how it may be treated in the future. A recent study using advanced single-cell RNA sequencing has identified four distinct subtypes of synovial sarcoma, each with unique biological features and potential treatment pathways. Why […]
A new Phase 1/2 trial in Ewing sarcoma, just profiled in Clinical Trial Vanguard and published in Nature Medicine, delivered the kind of result the synovial sarcoma community should be watching closely. The trial paired trabectedin with low-dose irinotecan to target the EWS::FLI1 fusion, the oncogenic driver of Ewing sarcoma. For more than a decade, […]
A recent case report highlights a rare GLI1-altered mesenchymal tumor presenting in the pleura (lining of the lung), a location where tumors can closely resemble synovial sarcoma. This case underscores a critical challenge in rare cancers — different tumors can appear similar under imaging and even under the microscope, making accurate diagnosis essential for appropriate […]
Advances in cell therapy for synovial sarcoma are creating more treatment options for patients with advanced disease. A recent update from Penn Medicine highlights the growing role of T-cell therapies in treating rare cancers like synovial sarcoma. What Is Afami-cel? Afamitresgene autoleucel (afami-cel) is the first FDA-approved T-cell receptor (TCR) therapy for adults with advanced […]
Synovial sarcoma is a rare soft tissue cancer that usually develops near joints in the arms or legs. However, in very rare cases, it can appear in unexpected places — including the pericardium, the lining around the heart. A recent case report describes a 23-year-old patient diagnosed with primary pericardial synovial sarcoma, an extremely uncommon […]
Synovial sarcoma is a rare soft tissue cancer that most commonly develops near the joints of the arms or legs. In extremely rare cases, it can arise in unexpected locations — including the heart. A recent case report highlights primary cardiac synovial sarcoma, an exceptionally uncommon presentation that underscores the complexity of diagnosing and treating […]