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A landmark study from Jerby-Arnon, Neftel, Shore, and colleagues at the Broad Institute of Harvard and MIT, Massachusetts General Hospital, Dana-Farber Cancer Institute, and the University of Lausanne used single-cell RNA sequencing to profile 16,872 individual cells from 12 human synovial sarcoma tumors – one of the most detailed cellular portraits of this disease ever […]
A 2022 study explored how sarcoma patients feel about long-term surveillance imaging after treatment, highlighting the emotional, financial, and practical challenges that can come with ongoing follow-up care. The study, led by Sarah C. Tepper, Anna K. Holten, Cara A. Cipriano, and colleagues evaluated patient concerns surrounding surveillance imaging through the “Sarcoma Surveillance Survey.” The […]
Synovial sarcoma is a rare soft tissue cancer that usually develops near joints in the arms or legs. However, in very rare cases, it can appear in unexpected places — including the pericardium, the lining around the heart. A recent case report describes a 23-year-old patient diagnosed with primary pericardial synovial sarcoma, an extremely uncommon […]
Most synovial sarcoma tumors develop in the soft tissues near the joints of the arms or legs in adolescents and young adults. However, physicians occasionally encounter rare presentations in other organs. A recent case report describes primary synovial sarcoma of the lung in a young child, highlighting how difficult rare pediatric sarcomas can be to […]
Synovial sarcoma is a rare and often aggressive cancer that can become difficult to treat once it spreads. Traditional chemotherapy options are limited, and outcomes for metastatic disease remain poor. New research is exploring whether advanced T-cell therapies may offer another option. A recent clinical trial evaluated afamitresgene autoleucel (afami-cel), an engineered T-cell therapy designed […]
Synovial sarcoma is driven by a defining genetic event — the SS18-SSX fusion protein, present in nearly all cases. For years, research and therapeutic development have focused on how this fusion interacts with the SWI/SNF chromatin remodeling complex, believed to play a central role in tumor growth. However, newly published research challenges that long-standing assumption […]
Join the Synovial Sarcoma Foundation for a live, one-hour webinar focused on where synovial sarcoma research is heading and what that progress means for patients and families today. The conversation will bring together real patient experiences with insights from researchers and clinicians leading efforts in synovial sarcoma. We’ll discuss emerging research, areas of real momentum, […]
Synovial sarcoma most often develops near the large joints of the arms or legs, but in rare cases it can arise in the head and neck region. An especially uncommon presentation occurs in infants. A recently published case report describes synovial sarcoma originating in the parotid gland—the salivary gland located near the jaw and ear—in […]
UI Health Care has begun treating eligible patients with synovial sarcoma using a new form of immunotherapy known as T cell receptor (TCR) therapy. This treatment approach represents an important step forward in expanding access to innovative options for people facing advanced synovial sarcoma. A targeted immune-based approach TCR therapy is designed to help the […]
Researchers have studied prasterone—also known as DHEA (dehydroepiandrosterone)—as a potential treatment option for people with synovial sarcoma that has spread (metastatic) or cannot be removed through surgery. This clinical study was designed to better understand the safety of prasterone, determine appropriate dosing, and explore whether it could help slow or control disease progression. This trial […]
