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A case report by Ryan Toledo, Jennifer Khong, and colleagues (published August 31, 2026; DOI: 10.7812/TPP/26.039) describes only the third known synovial sarcoma arising from the hyoid bone, a small U-shaped bone in the neck. The patient, a 62-year-old man, remains disease-free years after treatment. The Case The patient had a slowly growing left-sided neck […]
Two clinical trials testing TCR-NK cell therapy for advanced synovial sarcoma are now recruiting patients, one in the United States and one in the United Kingdom. Both use donor-derived natural killer cells engineered to target proteins commonly found on synovial sarcoma tumors. What Is TCR-NK Cell Therapy? TCR-NK therapy works differently from the TCR-T cell […]
A new study published in PLOS One by Ji-Yong Sung, Jin-Hong Kim, and Yi-Jun Kim from Seoul National University and Ewha Womans University, South Korea, examines a type of cell found in the tissue surrounding tumors, called cancer-associated fibroblasts (CAFs), and asks whether they can predict how a sarcoma patient will respond to immunotherapy. What […]
New program invites patients, survivors, caregivers, and families to turn lived experience into advocacy. [Philadelphia, PA], September 1, 2026: This Childhood Cancer Awareness Month, the Synovial Sarcoma Foundation (SSF) is inviting patients, survivors, caregivers, and supporters to take their advocacy further. SSF has officially launched its Ambassador Program, an ongoing initiative for anyone connected to […]
A study published in Cytotherapy by Kayo Toishigawa, Kenta Magoori, Hiroyuki Sato, and colleagues at Hiroshima University, in collaboration with Repertoire Genesis Inc. and Kyoto University, presents a promising new method for producing genetically engineered T cells at industrial scale using a technique called Platinum TALEN. The research is built around NY-ESO-1, one of the […]
Merck and Moderna are making headlines after their personalized mRNA cancer vaccine entered Phase 3 clinical trials for melanoma. For most people, it is an exciting medical story. For the synovial sarcoma community, it is something more personal than that. What the Vaccine Is mRNA-4157, combined with Merck’s immunotherapy pembrolizumab, works by sequencing a patient’s […]
A new preclinical study published in Biomedicine and Pharmacotherapy by Tomohiro Miyazaki, Yudai Murayama, Naoki Oike, and colleagues from the Department of Pediatrics and Division of Orthopedic Surgery at Niigata University Graduate School of Medical and Dental Sciences, Japan, presents early but promising evidence for a CAR-T cell therapy designed for synovial sarcoma that does […]
Kaela Graham-Bowman’s story reached national audiences this year when she was featured on 60 Minutes Australia. An Afghanistan veteran and nurse, Kaela was diagnosed with synovial sarcoma in 2020 at age 28, while working as an oncology nurse herself. What followed was a six-year fight through surgery, chemotherapy, a devastating relapse, and eventually a groundbreaking […]
Zelluna ASA, a Norwegian biotech company pioneering allogeneic cell therapies for solid cancers, recently announced that the first patient has received the first dose of ZI-MA4-1 in the ZIMA-101 Phase 1 clinical trial. The treatment was administered at The Christie NHS Foundation Trust in Manchester, United Kingdom, the largest single-site cancer centre in Europe, marking […]
A case report in AME Case Reports by Yun Xiao, Zhourui Liu, and Sha Li of the Department of Ultrasound at Guizhou Medical University, China, documents a rare case of synovial sarcoma arising directly in the pulmonary artery, a location so uncommon that it was initially mistaken for a benign cardiac tumor. What the Case […]
