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A new study in Advanced Science (October 12, 2026) shows what becomes possible when patients donate tumor tissue and researchers pair it with detailed clinical and genetic data. The same idea drives the Synovial Sarcoma Registry and Biorepository, and every patient who joins makes the next study possible. What the study found Over ten years, […]
Our Chairman of the Board of Directors, Nathan Imperiale, was recently invited by Philip Leider, President of the Board of the Sarcoma Alliance, to present about the Synovial Sarcoma Foundation in a live webinar hosted by the Sarcoma Alliance. The conversation covered the Foundation’s origin story, our active research programs, and the resources available to […]
A case report by Ryan Toledo, Jennifer Khong, and colleagues (published August 31, 2026; DOI: 10.7812/TPP/26.039) describes only the third known synovial sarcoma arising from the hyoid bone, a small U-shaped bone in the neck. The patient, a 62-year-old man, remains disease-free years after treatment. The Case The patient had a slowly growing left-sided neck […]
Two clinical trials testing TCR-NK cell therapy for advanced synovial sarcoma are now recruiting patients, one in the United States and one in the United Kingdom. Both use donor-derived natural killer cells engineered to target proteins commonly found on synovial sarcoma tumors. What Is TCR-NK Cell Therapy? TCR-NK therapy works differently from the TCR-T cell […]
A new study published in PLOS One by Ji-Yong Sung, Jin-Hong Kim, and Yi-Jun Kim from Seoul National University and Ewha Womans University, South Korea, examines a type of cell found in the tissue surrounding tumors, called cancer-associated fibroblasts (CAFs), and asks whether they can predict how a sarcoma patient will respond to immunotherapy. What […]
New program invites patients, survivors, caregivers, and families to turn lived experience into advocacy. [Philadelphia, PA], September 1, 2026: This Childhood Cancer Awareness Month, the Synovial Sarcoma Foundation (SSF) is inviting patients, survivors, caregivers, and supporters to take their advocacy further. SSF has officially launched its Ambassador Program, an ongoing initiative for anyone connected to […]
A study published in Cytotherapy by Kayo Toishigawa, Kenta Magoori, Hiroyuki Sato, and colleagues at Hiroshima University, in collaboration with Repertoire Genesis Inc. and Kyoto University, presents a promising new method for producing genetically engineered T cells at industrial scale using a technique called Platinum TALEN. The research is built around NY-ESO-1, one of the […]
Merck and Moderna are making headlines after their personalized mRNA cancer vaccine entered Phase 3 clinical trials for melanoma. For most people, it is an exciting medical story. For the synovial sarcoma community, it is something more personal than that. What the Vaccine Is mRNA-4157, combined with Merck’s immunotherapy pembrolizumab, works by sequencing a patient’s […]
A new preclinical study published in Biomedicine and Pharmacotherapy by Tomohiro Miyazaki, Yudai Murayama, Naoki Oike, and colleagues from the Department of Pediatrics and Division of Orthopedic Surgery at Niigata University Graduate School of Medical and Dental Sciences, Japan, presents early but promising evidence for a CAR-T cell therapy designed for synovial sarcoma that does […]
Kaela Graham-Bowman’s story reached national audiences this year when she was featured on 60 Minutes Australia. An Afghanistan veteran and nurse, Kaela was diagnosed with synovial sarcoma in 2020 at age 28, while working as an oncology nurse herself. What followed was a six-year fight through surgery, chemotherapy, a devastating relapse, and eventually a groundbreaking […]
