INTERNATIONAL: Pasireotide As Maintenance Treatment In SynovialSarcoma And Desmoplastic Small Round Cell Tumor (PAMSARC)
Trial ID: NCT06456359
Phase: Phase 2
Status: Recruiting
Last Update Posted: January 2025
Eligibility: Individuals aged 13 to 50 with advanced synovial sarcoma or desmoplastic small round cell tumor expressing somatostatin receptors (SSTR2/3/5) who have completed standard intensive treatment and achieved stable disease, partial, or complete response.
Overview: This Phase 2 trial evaluates pasireotide (Signifor), a long-acting somatostatin analog, as maintenance therapy following standard treatment for synovial sarcoma and desmoplastic small round cell tumor. Somatostatin receptors SSTR2, SSTR3, and SSTR5 are frequently overexpressed in both tumor types, providing the rationale for targeting them after initial chemotherapy, surgery, or radiation. Participants receive monthly pasireotide injections for up to four years. The trial is designed to assess whether this targeted maintenance approach can delay or prevent disease relapse.
Preliminary Effectiveness: The trial aims to determine whether pasireotide can prolong progression-free survival and overall survival in patients with SSTR2/3/5-expressing advanced synovial sarcoma and desmoplastic small round cell tumor. No results have been posted to ClinicalTrials.gov at this time.

Study Contact: University Hospital Heidelberg

Treatment Centers: Germany