Overview: The Synovial Sarcoma Registry and Biorepository is the only registry dedicated exclusively to synovial sarcoma. By securely collecting medical information, imaging, and tissue samples, the registry enables researchers to better understand the disease, identify new treatment opportunities, and accelerate the development of more effective therapies. Following enrollment, participants share access to their medical records and may provide a blood or saliva sample. Tumor tissue from clinically indicated procedures may also be collected at no additional burden to the patient. Participants may be contacted every 6 to 12 months for treatment and outcome updates for up to 10 years. Genetic testing may be performed on submitted samples, and results will be returned if deemed clinically significant. All coordination is managed entirely by the CHOP study team at no cost to the patient or institution.