Profile Narrative: Irene first noticed a lump in her right leg in 2019. An initial ultrasound suggested it was a benign lipoma, and she was advised not to worry. Over the next several years, the lump continued to cause intermittent discomfort. By 2025, the pain had increased significantly, and Irene felt strongly that something was not right. In June 2025, she returned to her physician and insisted on further evaluation and removal despite prior reassurance. Additional imaging, including ultrasound and MRI, revealed concerning features, leading to a biopsy. On August 29, 2025, Irene was diagnosed with grade 2 synovial sarcoma of the right calf. Determined to receive specialized care, she sought out a sarcoma-focused team at Massachusetts General Hospital, where she began treatment under the care of Dr. Lozano and Dr. Cote, supported closely by nurse practitioners Judianne Henderson and Christina Kim. Irene began treatment with three cycles of AIM chemotherapy starting October 1, 2025, receiving infusions on days one through three of each 21-day cycle. Radiation therapy began shortly thereafter, delivered on weekdays between chemotherapy cycles. To preserve ovarian function and reduce the risk of early menopause, she also received Lupron injections prior to treatment. On January 7, 2026, Irene underwent surgical resection of the tumor. Her postoperative recovery included a five-day hospital stay. She is currently non–weight bearing and will require several months of physical therapy to regain strength and mobility in her calf. At present, she is awaiting final tumor pathology results, which will guide decisions regarding whether additional chemotherapy is recommended or if surveillance will follow. Looking ahead, Irene anticipates long-term monitoring with CT, PET, and MRI imaging over the coming decade. Outside of her diagnosis, Irene is a 37-year-old mother of three and stepmother to one. She is married to her husband Derek, whom she describes as her biggest supporter. Her children—Scarlett (11), Prudence (8), Claire (4), and Tucker (2)—are the driving force behind her determination to keep moving forward. Professionally, Irene works as a performance coach at Blue Cross Blue Shield of Massachusetts, where she helps colleagues and members navigate complex health insurance systems. She also coaches a local recreational swim team, allowing her to stay involved in her children’s activities and community. Before treatment, Irene was an avid hiker, biker, and swimmer, spending much of her free time outdoors with her family, particularly at her family’s home in Bethel, Maine. While cancer has temporarily limited these activities, she continues to stay engaged in her children’s lives and looks forward to returning fully to the outdoor pursuits she loves. Irene emphasizes the importance of leaning on a strong support system. With help from her husband, parents, extended family, friends, and community, her family has navigated the many logistical and emotional challenges of treatment. She encourages others to advocate for themselves, trust their instincts, prioritize nutrition and rest during treatment, and accept help when it is offered. She believes that even small moments—fresh air, quiet time with loved ones, or brief outdoor breaks—can make a meaningful difference during a difficult journey.